Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | RORB | Q92753 | 2/20 | 0.38 |
| ▸ | CTSA | P10619 | 4/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032913 | 0.88 | LPAR1 (0.42) | LPAR1LPAR3LPAR2CTSAKDM4E | |
| SCHEMBL4034108 | 0.88 | LPAR1 (0.44) | LPAR1LPAR3LPAR2KDM4EMAPT | |
| SCHEMBL4035115 | 0.86 | IP6K1 (0.40) | LPAR1LPAR3LPAR2RORCCTSA | |
| SCHEMBL4035057 | 0.86 | TP53 (0.41) | LPAR1LPAR3LPAR2RORBCTSA | |
| SCHEMBL4028781 | 0.86 | LPAR1 (0.42) | LPAR1LPAR3LPAR2CTSAKDM4E | |
| SCHEMBL4030964 | 0.85 | HDAC3 (0.39) | LPAR1LPAR3LPAR2CTSAKDM4E | |
| SCHEMBL4034159 | 0.85 | LPAR1 (0.44) | LPAR1LPAR3LPAR2CTSAKDM4E | |
| SCHEMBL15437576 | 0.83 | LPAR1 (0.43) | LPAR1LPAR3LPAR2KDM4EMAPT | |
| SCHEMBL4032476 | 0.83 | LPAR1 (0.43) | LPAR1LPAR3LPAR2CTSAKDM4E | |
| SCHEMBL4032925 | 0.83 | LPAR1 (0.42) | LPAR1LPAR3LPAR2RORCMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |