Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.41 |
| ▸ | ACP1 | P24666 | 4/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021555 | 0.93 | NT5E (0.48) | NT5EABCG2MAP4K4ACP1CLK4 | |
| SCHEMBL4023370 | 0.88 | NT5E (0.49) | NT5EABCG2MAP4K4ACP1DHODH | |
| SCHEMBL4031373 | 0.85 | ABCG2 (0.52) | NT5EABCG2MAP4K4ACP1DHODH | |
| SCHEMBL4025363 | 0.84 | ABCG2 (0.48) | NT5EABCG2MAP4K4ACP1DHODH | |
| SCHEMBL4026944 | 0.80 | CLK4 (0.47) | NT5EABCG2MAP4K4ACP1CLK4 | |
| SCHEMBL4028870 | 0.79 | CYP1A2 (0.47) | NT5EABCG2MAP4K4ACP1CLK4 | |
| SCHEMBL4816411 | 0.78 | ABCG2 (0.52) | NT5EABCG2MAP4K4ACP1DHODH | |
| SCHEMBL4823113 | 0.77 | ABCG2 (0.48) | ABCG2MAP4K4ACP1MAOBKDM4E | |
| SCHEMBL4028750 | 0.77 | ABCG2 (0.48) | ABCG2MAP4K4ACP1MAOBKDM4E | |
| SCHEMBL4029317 | 0.76 | CLK4 (0.48) | CLK4DHODHKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339690-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |