Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031373 | 0.85 | ABCG2 (0.52) | KMT2AMEN1DHODHADORA1ADORA2A | |
| SCHEMBL4031533 | 0.84 | LMNA (0.47) | CLK4CLK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4025363 | 0.84 | ABCG2 (0.48) | CYP3A4KMT2AMEN1DHODH | |
| SCHEMBL4023370 | 0.81 | NT5E (0.49) | MAPK1HSD17B10ALDH1A1HPGDCASP7 | |
| SCHEMBL4021555 | 0.80 | NT5E (0.48) | CLK4DHODH | |
| SCHEMBL4816411 | 0.78 | ABCG2 (0.52) | KMT2AMEN1DHODHADORA1POLB | |
| SCHEMBL4823113 | 0.77 | ABCG2 (0.48) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL4028750 | 0.77 | ABCG2 (0.48) | CYP1A2CYP3A4CYP2D6CYP2C19KMT2A | |
| SCHEMBL4028870 | 0.76 | CYP1A2 (0.47) | CLK4CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4032492 | 0.76 | NT5E (0.45) | CLK4KMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339690-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |