Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 6/20 | 0.44 |
| ▸ | HRH1 | P35367 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030252 | 0.81 | SCARB1 (0.70) | SCARB1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL13746624 | 0.81 | SCARB1 (0.60) | SCARB1HSD17B10KDM4ECNR2NPC1 | |
| SCHEMBL4030106 | 0.80 | SCARB1 (0.61) | SCARB1HSD17B10KDM4ENPC1KMT2A | |
| SCHEMBL4189175 | 0.80 | SCARB1 (0.69) | SCARB1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL4028758 | 0.80 | SCARB1 (0.72) | SCARB1HSD17B10CNR2NPC1 | |
| SCHEMBL4024931 | 0.80 | SCARB1 (0.69) | SCARB1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL4030140 | 0.80 | SCARB1 (0.59) | SCARB1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL4027183 | 0.80 | SCARB1 (0.70) | SCARB1HSD17B10KDM4EKMT2AALDH1A1 | |
| SCHEMBL4029504 | 0.80 | SCARB1 (0.68) | SCARB1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL4195549 | 0.80 | SCARB1 (0.68) | SCARB1HSD17B10KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |