Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL9 | O00512 | 1/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.49 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032605 | 1.00 | BCL9 (0.49) | BCL9CTNNB1PROKR1EPHX2CYP1A2 | |
| SCHEMBL4212066 | 1.00 | BCL9 (0.49) | BCL9CTNNB1PROKR1EPHX2CYP1A2 | |
| SCHEMBL4030003 | 0.86 | ALDH1A1 (0.47) | PROKR1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4034835 | 0.84 | HPGD (0.48) | BCL9CTNNB1PROKR1SMN1; SMN2HRH3 | |
| SCHEMBL4028589 | 0.83 | BCL9 (0.54) | BCL9CTNNB1PROKR1PDE4BRORC | |
| SCHEMBL4028580 | 0.83 | BCL9 (0.54) | BCL9CTNNB1PROKR1PDE4BRORC | |
| SCHEMBL4033307 | 0.83 | BCL9 (0.54) | BCL9CTNNB1PROKR1PDE4BRORC | |
| SCHEMBL4029545 | 0.82 | BCL9 (0.47) | BCL9CTNNB1PROKR1PDE4BMYC | |
| SCHEMBL4029539 | 0.82 | BCL9 (0.47) | BCL9CTNNB1PROKR1PDE4BMYC | |
| SCHEMBL4034960 | 0.82 | BCL9 (0.47) | BCL9CTNNB1PROKR1PDE4BMYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567493-B1 | PHENYL SUBSTITUTED PIPERIDINE COMPOUNDS FOR USE AS PPAR ACTIVATORS | PFIZER PROD INC (US) | 2009-03-18 | — | — | EP | disclosed |
| US-20070281935-A1 | Use | PFIZER INC. (US) | 2007-12-06 | — | — | US | disclosed |
| US-20070232647-A1 | Use of Ppar Agonists to Treat Ruminants | GOETZE LEOPOLD F | 2007-10-04 | — | — | US | disclosed |
| US-20070191429-A1 | PPAR ACTIVATORS | PFIZER INC. (US) | 2007-08-16 | — | — | US | disclosed |
| US-7199243-B2 | Piperidine compounds useful as PPAR activators | PFIZER INC. (US) | 2007-04-03 | — | — | US | disclosed |
| EP-1765320-A2 | USE OF PPAR AGONISTS TO TREAT RUMINANTS | Pfizer Products Incorporated (US) | 2007-03-28 | — | — | EP | disclosed |
| EP-1753426-A2 | RUMINANT TREATMENTS | Pfizer Products Incorporated (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005115369-A2 | USE OF PPAR AGONISTS TO TREAT RUMINANTS | PFIZER PRODUCTS INC. (US) | 2005-12-08 | — | — | WO | disclosed |
| WO-2005115389-A2 | SPECIFIC PPAR AGONISTS FOR TREATING NEGATIVE ENERGY BALANCE | PFIZER PRODUCTS INC. (US) | 2005-12-08 | — | — | WO | disclosed |
| EP-1567493-A1 | PHENYL SUBSTITUTED PIPERIDINE COMPOUNDS FOR USE AS PPAR ACTIVATORS | Pfizer Products Inc. (US) | 2005-08-31 | — | — | EP | disclosed |
| US-20040157885-A1 | PPAR activators | PFIZER INC | 2004-08-12 | — | — | US | disclosed |
| WO-2004048334-A1 | PHENYL SUBSTITUTED PIPERIDINE COMPOUNDS FOR USE AS PPAR ACTIVATORS | PFIZER PRODUCTS INC. (US) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191429-A1 | PPAR ACTIVATORS | PPARA, PPARG, PPARD | BCL9 2684/4885CTNNB1 2280/4885PROKR1 949/4885 |
| US-20040157885-A1 | PPAR activators | PPARA, PPARG, PPARD | BCL9 2684/4885CTNNB1 2280/4885PROKR1 949/4885 |
| US-20070281935-A1 | Use | ALPP, CPT1A, PIGS | BCL9 3385/4885CTNNB1 995/4885PROKR1 614/4885 |
| US-20070232647-A1 | Use of Ppar Agonists to Treat Ruminants | PPARG, PPARD, PPARA | BCL9 3397/4885CTNNB1 1557/4885PROKR1 541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.