SCHEMBL4032846

SCHEMBL4032846

O=c1[nH]cccc1N1CCOCC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
MEN1 O00255 1/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
KMT2A Q03164 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
HSD17B10 Q99714 3/20 0.46
ALOX15 P16050 1/20 0.46
IRAK4 Q9NWZ3 1/20 0.43
ALDH1A1 P00352 3/20 0.43
PRKDC P78527 3/20 0.43
KDM4E B2RXH2 2/20 0.43
APAF1 O14727 1/20 0.42
CDC25B P30305 1/20 0.42
CASP3 P42574 1/20 0.42
SENP8 Q96LD8 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
LMNA P02545 3/20 0.41
POLB P06746 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9234686 0.83 MAPT (0.46) MAPTL3MBTL1NPC1RAB9AALDH1A1
SCHEMBL28807259 0.81 MAPT (0.49) MAPTL3MBTL1NPC1RAB9AALDH1A1
SCHEMBL9933428 0.80 ADRB1 (0.52) MAPTHSD17B10ALDH1A1KDM4ELMNA
SCHEMBL1536526 0.79 CTSB (0.47) MAPTL3MBTL1MEN1NPC1RAB9A
Hydrochloric Acid SCHEMBL29277728 0.77 MAPT (0.41) MAPTL3MBTL1MEN1NPC1RAB9A
SCHEMBL3833537 0.75 LMNA (0.48) MAPTMEN1NPC1RAB9AKMT2A
SCHEMBL9424119 0.74 LMNA (0.62) MAPTL3MBTL1MEN1NPC1RAB9A
SCHEMBL28025203 0.73 ATR (0.35) ALDH1A1KDM4E
SCHEMBL20025114 0.73 SLC6A2 (0.38) IRAK4ALDH1A1
SCHEMBL31133207 0.71 CYP2A13 (0.53) MEN1KMT2AHSD17B10ALOX15ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024153155-A1 DOUBLE-HETEROCYCLIC WRN INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF 成都微芯药业有限公司 2024-07-25 WO claimed
WO-2026107076-A1 CDK2 INHIBITOR COMPOUNDS ALEKSIA THERAPEUTICS, INC. (US) 2026-05-21 WO disclosed
WO-2024153155-A1 DOUBLE-HETEROCYCLIC WRN INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF 成都微芯药业有限公司 2024-07-25 WO disclosed
US-20230234949-A1 MORPHOLINYLPYRIDONE COMPOUNDS SPRINT BIOSCIENCE AB (SE) 2023-07-27 US disclosed
CN-116462674-A Morpholinyl pyridone compounds 思普瑞特生物科学公司 2023-07-21 CN disclosed
CN-116462674-A Morpholinyl pyridone compounds 思普瑞特生物科学公司 2023-07-21 CN disclosed
CN-116462674-A Morpholinyl pyridone compounds 思普瑞特生物科学公司 2023-07-21 CN disclosed
CN-116444510-A Morpholinyl pyridone compounds 思普瑞特生物科学公司 2023-07-18 CN disclosed
CN-116444510-A Morpholinyl pyridone compounds 思普瑞特生物科学公司 2023-07-18 CN disclosed
CN-116444510-A Morpholinyl pyridone compounds 思普瑞特生物科学公司 2023-07-18 CN disclosed
EP-4056569-A1 MORPHOLINYLPYRIDONE COMPOUNDS Sprint Bioscience AB (SE) 2022-09-14 EP disclosed
EP-3672962-B1 MORPHOLINYLPYRIDONE COMPOUNDS SPRINT BIOSCIENCE AB (SE) 2022-01-26 EP disclosed
CN-111108102-A Morpholinopyridone compounds 思普瑞特生物科学公司 2020-05-05 CN disclosed
CN-111108102-A Morpholinopyridone compounds 思普瑞特生物科学公司 2020-05-05 CN disclosed
CN-111108102-A Morpholinopyridone compounds 思普瑞特生物科学公司 2020-05-05 CN disclosed
EP-3042900-A1 NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF Fujifilm Corporation (JP) 2016-07-13 EP disclosed
CN-105143209-A Biaryl amide compounds as kinase inhibitors NOVARTIS AG 2015-12-09 CN disclosed
EP-1613613-A4 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC (CA) 2009-03-25 EP disclosed
EP-1613613-A2 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC. (CA) 2006-01-11 EP disclosed
WO-2004091518-A2 CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS ANORMED INC. (CA) 2004-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230234949-A1 MORPHOLINYLPYRIDONE COMPOUNDS MAP1B, RRP12, MYT1 MAPT 60/4885L3MBTL1 2793/4885MEN1 76/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.