Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.43 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032394 | 0.88 | LPAR1 (0.47) | LPAR1LPAR2LPAR3MEN1KMT2A | |
| SCHEMBL4033590 | 0.87 | LPAR1 (0.47) | LPAR1LPAR2LPAR3TSHRSMN1; SMN2 | |
| SCHEMBL4033523 | 0.87 | LPAR1 (0.43) | LPAR1LPAR2LPAR3TSHRSMN1; SMN2 | |
| SCHEMBL4034939 | 0.86 | LPAR1 (0.45) | LPAR1LPAR2LPAR3MEN1KMT2A | |
| SCHEMBL4028841 | 0.85 | LPAR1 (0.43) | LPAR1LPAR2LPAR3TSHRSMN1; SMN2 | |
| SCHEMBL4036696 | 0.84 | LPAR1 (0.44) | LPAR1LPAR2LPAR3SMN1; SMN2MEN1 | |
| SCHEMBL4034499 | 0.83 | LPAR1 (0.48) | LPAR1LPAR2LPAR3MEN1KMT2A | |
| SCHEMBL4036454 | 0.83 | LPAR1 (0.43) | LPAR1LPAR2LPAR3SMN1; SMN2MEN1 | |
| SCHEMBL4034108 | 0.82 | LPAR1 (0.44) | LPAR1LPAR2LPAR3SMN1; SMN2MEN1 | |
| SCHEMBL4030241 | 0.82 | LPAR1 (0.42) | ATMLPAR1LPAR2LPAR3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |