Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.42 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.36 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028841 | 0.93 | LPAR1 (0.43) | LPAR1LPAR2LPAR3ALDH1A1CYP1A2 | |
| SCHEMBL4036454 | 0.89 | LPAR1 (0.43) | LPAR1LPAR2LPAR3HTR5AALDH1A1 | |
| SCHEMBL4034939 | 0.87 | LPAR1 (0.45) | LPAR1LPAR2LPAR3HTR5AALDH1A1 | |
| SCHEMBL4031158 | 0.87 | MEN1 (0.43) | LPAR1LPAR2LPAR3HTR5AALDH1A1 | |
| SCHEMBL4032394 | 0.86 | LPAR1 (0.47) | LPAR1LPAR2LPAR3KDM4E | |
| SCHEMBL4036696 | 0.85 | LPAR1 (0.44) | LPAR1LPAR2LPAR3KDM4E | |
| SCHEMBL4032920 | 0.82 | ATM (0.44) | LPAR1LPAR2LPAR3ALDH1A1TDP1 | |
| SCHEMBL4034499 | 0.81 | LPAR1 (0.48) | LPAR1LPAR2LPAR3ALDH1A1KDM4E | |
| SCHEMBL4034108 | 0.80 | LPAR1 (0.44) | LPAR1LPAR2LPAR3ALDH1A1LMNA | |
| SCHEMBL4034918 | 0.80 | LPAR1 (0.45) | LPAR1LPAR2LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |