Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033251 | 0.84 | MAPK14 (0.40) | TGFBR1MAPK14KDRRIPK2 | |
| SCHEMBL4031950 | 0.82 | MAPK14 (0.40) | TGFBR1MAPK14KDRRIPK2 | |
| SCHEMBL4032576 | 0.76 | MAPK14 (0.44) | TGFBR1MAPK14KDR | |
| SCHEMBL4032785 | 0.74 | TGFBR1 (0.62) | TGFBR1MAPK14KDRRIPK2 | |
| SCHEMBL4034944 | 0.72 | TGFBR1 (0.53) | TGFBR1MAPK14KDR | |
| SCHEMBL3723641 | 0.72 | CCR1 (0.58) | TGFBR1 | |
| SCHEMBL4032610 | 0.71 | TGFBR1 (0.60) | TGFBR1MAPK14 | |
| SCHEMBL18543857 | 0.70 | ALDH1A1 (0.48) | TGFBR1 | |
| SCHEMBL4034948 | 0.70 | TGFBR1 (0.45) | TGFBR1 | |
| SCHEMBL16526730 | 0.70 | TGFBR1 (0.53) | TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542994-B1 | NOVEL OXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITOR | PFIZER PROD INC (US) | 2009-04-29 | — | — | EP | claimed |