Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 17/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031950 | 0.91 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| SCHEMBL4032942 | 0.84 | TGFBR1 (0.39) | MAPK14TGFBR1KDRRIPK2 | |
| SCHEMBL4030453 | 0.76 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11TGFBR1 | |
| SCHEMBL4032537 | 0.74 | TGFBR1 (0.58) | MAPK14TGFBR1KDRRIPK2 | |
| SCHEMBL4035598 | 0.72 | TGFBR1 (0.51) | MAPK14TGFBR1KDRNPC1 | |
| SCHEMBL3723641 | 0.72 | CCR1 (0.58) | TGFBR1KDM4ENPC1GAAHSD17B10 | |
| SCHEMBL4032807 | 0.71 | TGFBR1 (0.57) | MAPK14TGFBR1KDM4ENPC1HSD17B10 | |
| SCHEMBL18543857 | 0.70 | ALDH1A1 (0.48) | TGFBR1KDM4ENPC1GAAHSD17B10 | |
| SCHEMBL4035600 | 0.70 | TGFBR1 (0.43) | TGFBR1ATRKDM4E | |
| SCHEMBL16526730 | 0.70 | TGFBR1 (0.53) | MAPK14TGFBR1NPC1GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542994-B1 | NOVEL OXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITOR | PFIZER PROD INC (US) | 2009-04-29 | — | — | EP | claimed |