Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034499 | 0.89 | LPAR1 (0.48) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4034111 | 0.89 | BRD4 (0.37) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4034923 | 0.89 | MEN1 (0.34) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4030980 | 0.83 | IP6K1 (0.38) | LPAR1LPAR3LPAR2TP53PPARG | |
| SCHEMBL4029114 | 0.82 | HDAC6 (0.40) | LPAR1LPAR3MEN1KMT2ATP53 | |
| SCHEMBL4032476 | 0.81 | LPAR1 (0.43) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4030341 | 0.79 | LPAR1 (0.39) | LPAR1LPAR3LPAR2ALDH1A1HDAC3 | |
| SCHEMBL4034108 | 0.79 | LPAR1 (0.44) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4032925 | 0.79 | LPAR1 (0.42) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL4029083 | 0.79 | LPAR1 (0.48) | LPAR1LPAR3LPAR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |