Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.32 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037774 | 0.88 | LPAR1 (0.33) | LPAR1MAPTHDAC4HDAC1HDAC7 | |
| SCHEMBL4031683 | 0.84 | TRPA1 (0.43) | LPAR1LPAR3ALDH1A1S1PR3 | |
| SCHEMBL4033264 | 0.79 | LPAR1 (0.40) | LPAR1LPAR3LPAR2MAPTHDAC1 | |
| SCHEMBL4034499 | 0.78 | LPAR1 (0.48) | LPAR1LPAR3LPAR2MAPTHDAC1 | |
| SCHEMBL16060790 | 0.76 | POLB (0.38) | LPAR1LPAR3LPAR2MAPTHDAC1 | |
| SCHEMBL4033561 | 0.73 | LPAR1 (0.42) | LPAR1LPAR3KDM4EALDH1A1ABCC3 | |
| SCHEMBL4028121 | 0.73 | LPAR1 (0.44) | LPAR1LPAR3MAPTKDM4EALDH1A1 | |
| SCHEMBL4030691 | 0.73 | LPAR1 (0.41) | LPAR1LPAR3MAPTABCC3ABCC4 | |
| SCHEMBL4033953 | 0.73 | LPAR1 (0.41) | LPAR1LPAR3S1PR1S1PR3 | |
| SCHEMBL4035140 | 0.72 | KMT2A (0.44) | MAPTHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |