Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 15/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029883 | 0.75 | TGFBR1 (0.39) | TGFBR1MAPK14CCR1CCR8MAPK13 | |
| SCHEMBL4032039 | 0.73 | FAAH (0.38) | TGFBR1MAPK14CCR1CCR8MAPK13 | |
| SCHEMBL4032537 | 0.72 | TGFBR1 (0.58) | TGFBR1MAPK14RIPK2ACVR1BMTOR | |
| SCHEMBL4030943 | 0.71 | TGFBR1 (0.57) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL4035598 | 0.71 | TGFBR1 (0.51) | TGFBR1MAPK14MTOR | |
| SCHEMBL4033073 | 0.66 | TGFBR1 (0.42) | TGFBR1MAPK14CCR1CCR8MTOR | |
| SCHEMBL4030453 | 0.65 | MAPK14 (0.44) | TGFBR1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4033251 | 0.65 | MAPK14 (0.40) | TGFBR1MAPK14RIPK2MAPK13MAPK12 | |
| SCHEMBL4029836 | 0.64 | TGFBR1 (0.38) | TGFBR1MAPK14CCR1CCR8 | |
| SCHEMBL4031270 | 0.63 | TGFBR1 (0.62) | TGFBR1MAPK14RIPK2ACVR1BMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542994-B1 | NOVEL OXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITOR | PFIZER PROD INC (US) | 2009-04-29 | — | — | EP | claimed |