Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.49 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.49 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036981 | 0.89 | MAPT (0.45) | LPAR1LPAR3LPAR2KDM4EMAPT | |
| SCHEMBL4029811 | 0.89 | LPAR1 (0.57) | LPAR1LPAR3LPAR2KDM4EMAPT | |
| SCHEMBL4034283 | 0.83 | LPAR1 (0.74) | LPAR1LPAR3LPAR2KDM4EMAPT | |
| SCHEMBL4031711 | 0.82 | MAPT (0.51) | LPAR1LPAR3LPAR2KDM4EMAPT | |
| SCHEMBL4032711 | 0.80 | LPAR1 (0.48) | LPAR1LPAR3LPAR2KDM4EMAPT | |
| SCHEMBL4035675 | 0.78 | MAPT (0.67) | LPAR1LPAR3LPAR2KDM4EMAPT | |
| SCHEMBL4032632 | 0.78 | LPAR1 (0.47) | LPAR1LPAR3LPAR2KDM4EMAPT | |
| SCHEMBL4034651 | 0.78 | LPAR1 (0.41) | LPAR1LPAR3LPAR2KDM4EMAPT | |
| SCHEMBL4034142 | 0.77 | LPAR1 (0.54) | LPAR1LPAR3LPAR2KDM4EMAPT | |
| SCHEMBL4034814 | 0.77 | MAPT (0.53) | LPAR1LPAR3KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |