Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.47 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032711 | 0.88 | LPAR1 (0.48) | LPAR1LPAR3MAPTKDM4EFFAR1 | |
| SCHEMBL4031711 | 0.83 | MAPT (0.51) | LPAR1LPAR3MAPTKDM4EFFAR1 | |
| SCHEMBL4036981 | 0.82 | MAPT (0.45) | LPAR1LPAR3MAPTKDM4EFFAR1 | |
| SCHEMBL4033624 | 0.81 | LPAR1 (0.66) | LPAR1LPAR3MAPTKDM4ELPAR2 | |
| SCHEMBL4034814 | 0.79 | MAPT (0.53) | LPAR1LPAR3MAPTKDM4ENPC1 | |
| SCHEMBL4033847 | 0.78 | LPAR1 (0.49) | LPAR1LPAR3MAPTKDM4EFFAR1 | |
| SCHEMBL4035675 | 0.77 | MAPT (0.67) | LPAR1LPAR3MAPTKDM4ELPAR2 | |
| SCHEMBL4030049 | 0.77 | MAPT (0.60) | LPAR1LPAR3MAPTKDM4ELPAR2 | |
| SCHEMBL4037473 | 0.77 | MAPT (0.51) | LPAR1LPAR3MAPTKDM4ELPAR2 | |
| SCHEMBL4034651 | 0.75 | LPAR1 (0.41) | LPAR1LPAR3MAPTKDM4EFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |