Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.44 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034108 | 0.91 | LPAR1 (0.44) | LPAR1LPAR3LPAR2LMNANPSR1 | |
| SCHEMBL4034159 | 0.90 | LPAR1 (0.44) | LPAR1LPAR3LPAR2LMNANPSR1 | |
| SCHEMBL4030024 | 0.89 | LPAR1 (0.42) | LPAR1LPAR3LPAR2NPSR1GPBAR1 | |
| SCHEMBL15437576 | 0.88 | LPAR1 (0.43) | LPAR1LPAR3LPAR2LMNAKMT2A | |
| SCHEMBL4032476 | 0.88 | LPAR1 (0.43) | LPAR1LPAR3LPAR2LMNACTSA | |
| SCHEMBL4029083 | 0.87 | LPAR1 (0.48) | LPAR1LPAR3LPAR2KMT2AMEN1 | |
| SCHEMBL4032913 | 0.87 | LPAR1 (0.42) | LPAR1LPAR3LPAR2LMNANPSR1 | |
| SCHEMBL4034499 | 0.86 | LPAR1 (0.48) | LPAR1LPAR3LPAR2KMT2AMEN1 | |
| SCHEMBL4029159 | 0.86 | LPAR1 (0.47) | LPAR1LPAR3LPAR2 | |
| SCHEMBL4036790 | 0.85 | TRPA1 (0.46) | LPAR1LPAR3LPAR2CTSABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |