Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3096459 | 0.89 | POLB (0.55) | SMN1; SMN2CYP2C19POLBMEN1KMT2A | |
| SCHEMBL3560869 | 0.86 | SMN1; SMN2 (0.67) | SMN1; SMN2CYP2C19POLBMEN1KMT2A | |
| SCHEMBL3504514 | 0.84 | HCAR2 (0.51) | SMN1; SMN2POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL27812150 | 0.81 | ATM (0.51) | SMN1; SMN2CYP2C19ALDH1A1NPC1RAB9A | |
| SCHEMBL3503104 | 0.80 | FKBP1A (0.54) | SMN1; SMN2CYP2C19POLBALDH1A1L3MBTL1 | |
| SCHEMBL27694957 | 0.77 | AKR1B10 (0.47) | SMN1; SMN2CYP2C19MEN1KMT2AALDH1A1 | |
| SCHEMBL28514277 | 0.75 | LMNA (0.60) | SMN1; SMN2POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL14107690 | 0.75 | MAPT (0.51) | CYP2C19POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL1222959 | 0.75 | POLB (0.71) | SMN1; SMN2CYP2C19POLBMEN1KMT2A | |
| SCHEMBL6623958 | 0.75 | CHRM5 (0.44) | SMN1; SMN2MEN1KMT2AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501467-A4 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-1501467-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | Bristol-Myers Squibb Company (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003088908-A2 | HETEROCYCLO INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-10-30 | — | — | WO | disclosed |