Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034857 | 0.89 | HRH3 (0.48) | HRH3HRH1PARP1ADRA1AACKR3 | |
| SCHEMBL4034675 | 0.89 | PARP1 (0.42) | HRH3HRH1PARP1ADRA1ASMO | |
| SCHEMBL4031091 | 0.87 | HRH3 (0.51) | HRH3ADRA1ASMO | |
| SCHEMBL5211294 | 0.87 | HRH3 (0.50) | HRH3HRH1PARP1PARP2 | |
| SCHEMBL4032468 | 0.86 | HRH3 (0.42) | HRH3ADRA1ASMO | |
| SCHEMBL4034618 | 0.85 | HRH3 (0.41) | HRH3ADRA1AACKR3 | |
| Hydrochloric Acid SCHEMBL4037289 | 0.85 | HRH3 (0.41) | HRH3ADRA1ASMO | |
| SCHEMBL4032017 | 0.84 | HRH3 (0.53) | HRH3HRH1PARP1PARP2 | |
| SCHEMBL5209745 | 0.78 | HRH3 (0.49) | HRH3HRH1PARP1 | |
| SCHEMBL5456526 | 0.77 | HRH3 (0.61) | HRH3HRH1PARP1PARP2SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7638631-B2 | Methylene dipiperidine derivatives | GLAXO GROUP LIMITED (GB) | 2009-12-29 | — | — | US | claimed |
| EP-1789410-B1 | METHYLENE DIPIPERIDINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2009-06-17 | — | — | EP | claimed |
| US-20080108624-A1 | Methylene Dipiperidine Derivatives | GLAXO GROUP LIMITED (GB) | 2008-05-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108624-A1 | Methylene Dipiperidine Derivatives | DRD2, DRD4, PNMT | HRH3 620/4885HRH1 658/4885PARP1 803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.