Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034389 | 0.90 | TRPA1 (0.39) | LPAR1LPAR3LPAR2LMNATP53 | |
| SCHEMBL4033456 | 0.89 | LPAR1 (0.39) | LPAR1LPAR3LPAR2HTTLMNA | |
| SCHEMBL4034108 | 0.85 | LPAR1 (0.44) | LPAR1LPAR3LPAR2LMNANPSR1 | |
| SCHEMBL4034923 | 0.81 | MEN1 (0.34) | LPAR1LPAR3LPAR2LMNANPSR1 | |
| SCHEMBL4034159 | 0.80 | LPAR1 (0.44) | LPAR1LPAR3LPAR2HTTLMNA | |
| SCHEMBL4032913 | 0.80 | LPAR1 (0.42) | LPAR1LPAR3LPAR2HTTLMNA | |
| SCHEMBL4034499 | 0.79 | LPAR1 (0.48) | LPAR1LPAR3LPAR2MEN1KMT2A | |
| SCHEMBL15437576 | 0.79 | LPAR1 (0.43) | LPAR1LPAR3LPAR2LMNAMEN1 | |
| SCHEMBL4032476 | 0.79 | LPAR1 (0.43) | LPAR1LPAR3LPAR2LMNATSHR | |
| SCHEMBL4034918 | 0.78 | LPAR1 (0.45) | LPAR1LPAR3LPAR2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |