Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032439 | 0.86 | KMT2A (0.47) | KMT2AMAPTMEN1ALDH1A1GPR119 | |
| SCHEMBL4038173 | 0.86 | KMT2A (0.49) | KMT2AMAPTMEN1ALDH1A1GPR119 | |
| SCHEMBL4032437 | 0.85 | KMT2A (0.48) | KMT2AMAPTMEN1ALDH1A1GPR119 | |
| SCHEMBL4032425 | 0.85 | HRH1 (0.48) | KMT2AMAPTMEN1ALDH1A1GPR119 | |
| SCHEMBL4032905 | 0.83 | KMT2A (0.57) | KMT2AMAPTMEN1ALDH1A1HDAC3 | |
| SCHEMBL336009 | 0.81 | NPC1 (0.65) | KMT2AMAPTMEN1ALDH1A1HDAC3 | |
| SCHEMBL24725744 | 0.81 | USP2 (0.53) | KMT2AMAPTMEN1ALDH1A1GPR119 | |
| SCHEMBL3770035 | 0.81 | USP2 (0.53) | KMT2AMAPTMEN1ALDH1A1GPR119 | |
| SCHEMBL24725739 | 0.81 | KMT2A (0.53) | KMT2AMAPTMEN1ALDH1A1GPR119 | |
| SCHEMBL13460553 | 0.78 | KMT2A (0.51) | KMT2AMAPTMEN1ALDH1A1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789410-B1 | METHYLENE DIPIPERIDINE DERIVATIVES | GLAXO GROUP LTD (GB) | 2009-06-17 | — | — | EP | claimed |
| US-20080108624-A1 | Methylene Dipiperidine Derivatives | GLAXO GROUP LIMITED (GB) | 2008-05-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108624-A1 | Methylene Dipiperidine Derivatives | DRD2, DRD4, PNMT | KMT2A 713/4885MAPT 120/4885MEN1 3050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.