Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.46 |
| ▸ | IL6 | P05231 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954991 | 0.91 | PIK3C2B (0.50) | TLR7PIK3C2BIL6PDE10ASMN1; SMN2 | |
| SCHEMBL4035856 | 0.76 | TLR7 (0.49) | TLR7IL6SMN1; SMN2LMNASTAT6 | |
| SCHEMBL13906412 | 0.69 | HPGD (0.42) | TLR7SMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL3957931 | 0.68 | L3MBTL1 (0.42) | SMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL24402238 | 0.68 | PIK3CA (0.46) | LMNAPKMDYRK1AKDM4EALDH1A1 | |
| SCHEMBL26071991 | 0.68 | HDAC1 (0.47) | PKMKDM4EALDH1A1 | |
| SCHEMBL6300528 | 0.68 | PIK3C2B (0.53) | PIK3C2BSMN1; SMN2LMNAKDM4E | |
| SCHEMBL2060258 | 0.67 | TLR7 (0.74) | TLR7IL6 | |
| SCHEMBL4040897 | 0.66 | TLR7 (0.50) | TLR7IL6ALDH1A1 | |
| SCHEMBL3963207 | 0.66 | HRH4 (0.54) | SMN1; SMN2LMNAPKMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | claimed |
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |