Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 9/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043014 | 0.89 | MAPK10 (0.35) | MAPK10MAPK9IKBKBMEN1KMT2A | |
| SCHEMBL6315675 | 0.78 | NPC1 (0.35) | MAPK10MAPK9MEN1KMT2ANPC1 | |
| SCHEMBL4042505 | 0.73 | ALDH1A1 (0.40) | MEN1KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL4042444 | 0.73 | ALDH1A1 (0.39) | MEN1KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL4045782 | 0.71 | MAPT (0.36) | MAPK10MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL4045354 | 0.71 | GCGR (0.40) | MAPK10MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL4042394 | 0.70 | GRM1 (0.36) | MAPK10MAPK9MEN1KMT2AALDH1A1 | |
| SCHEMBL4038702 | 0.70 | MAPT (0.38) | MEN1KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL4040360 | 0.69 | GCGR (0.49) | MEN1KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL4046896 | 0.69 | GCGR (0.37) | MEN1KMT2ANPC1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549655-B1 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | claimed |