Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 16/20 | 0.80 |
| ▸ | GABRA1 | P14867 | 14/20 | 0.67 |
| ▸ | PDE1A | P54750 | 4/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225842 | 0.89 | GABRA5 (1.00) | GABRA5GABRA1PDE1APDE1BPDE1C | |
| SCHEMBL17421084 | 0.81 | GABRA5 (0.69) | GABRA5GABRA1PDE1APDE1BPDE1C | |
| SCHEMBL7979884 | 0.78 | GABRA5 (0.68) | GABRA5GABRA1 | |
| SCHEMBL31475446 | 0.75 | PDE5A (0.50) | GABRA5GABRA1PDE1APDE1BPDE1C | |
| SCHEMBL18185736 | 0.74 | GABRA5 (0.60) | GABRA5PDE1APDE1BPDE1C | |
| SCHEMBL4042951 | 0.73 | PDE5A (0.54) | GABRA5PDE1APDE1BPDE1C | |
| SCHEMBL14919807 | 0.73 | GABRA5 (0.59) | GABRA5GABRA1PDE1APDE1BPDE1C | |
| SCHEMBL14195213 | 0.72 | GABRA5 (0.49) | GABRA5GABRA1PDE1APDE1BPDE1C | |
| SCHEMBL19946112 | 0.72 | AAK1 (0.56) | GABRA5GABRA1PDE1APDE1BPDE1C | |
| SCHEMBL14195200 | 0.72 | GABRA5 (0.47) | GABRA5GABRA1PDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | disclosed |