Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 18/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 13/20 | 0.68 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.53 |
| ▸ | PDE1A | P54750 | 1/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036357 | 0.89 | GABRA5 (0.80) | GABRA5GABRA1PDE1APDE1BPDE1C | |
| SCHEMBL17421084 | 0.81 | GABRA5 (0.69) | GABRA5GABRA1P2RX4PDE1APDE1B | |
| SCHEMBL7979884 | 0.81 | GABRA5 (0.68) | GABRA5GABRA1 | |
| SCHEMBL9655188 | 0.77 | GABRA5 (1.00) | GABRA5GABRA1 | |
| SCHEMBL18185736 | 0.75 | GABRA5 (0.60) | GABRA5PDE1APDE1BPDE1C | |
| SCHEMBL14919807 | 0.74 | GABRA5 (0.59) | GABRA5GABRA1PDE1APDE1BPDE1C | |
| SCHEMBL7323981 | 0.72 | GABRA5 (0.71) | GABRA5GABRA1P2RX4PDE1APDE1B | |
| SCHEMBL7225918 | 0.71 | MEN1 (0.70) | GABRA5P2RX4 | |
| SCHEMBL30934954 | 0.71 | MEN1 (0.70) | GABRA5P2RX4 | |
| SCHEMBL25843777 | 0.71 | GABRA5 (0.55) | GABRA5P2RX4PDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6635626-B1 | T-cell mediated disorders | BRISTOL-MYERS SQUIBB CO. | 2003-10-21 | — | — | US | disclosed |
| US-6239133-B1 | IMMUNOLOGIC DISORDERS. | BRISTOL-MYERS SQUIBB COMPANY | 2001-05-29 | — | — | US | disclosed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |