Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | GAA | P10253 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | CASP1 | P29466 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14408979 | 0.81 | MAPT (0.43) | BPTFMAPTALDH1A1GAAHSD17B10 | |
| SCHEMBL4040868 | 0.72 | GCGR (0.48) | ALDH1A1GAAMEN1KMT2APOLB | |
| SCHEMBL4035961 | 0.69 | BPTF (0.78) | BPTFMAPTALDH1A1GAAHSD17B10 | |
| SCHEMBL3765697 | 0.66 | BPTF (0.54) | BPTFMAPTALDH1A1GAAHSD17B10 | |
| SCHEMBL1514467 | 0.64 | BPTF (0.92) | BPTFMAPTALDH1A1GAAHSD17B10 | |
| SCHEMBL620749 | 0.64 | BPTF (1.00) | BPTFMAPTALDH1A1GAAHSD17B10 | |
| SCHEMBL21605422 | 0.64 | MAPT (0.64) | BPTFMAPTALDH1A1GAAHSD17B10 | |
| SCHEMBL31381502 | 0.63 | BPTF (0.96) | BPTFMAPTALDH1A1GAAHSD17B10 | |
| SCHEMBL1719516 | 0.63 | ALDH1A1 (1.00) | BPTFMAPTALDH1A1GAAHSD17B10 | |
| SCHEMBL3421133 | 0.62 | BPTF (1.00) | BPTFMAPTALDH1A1GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549655-B1 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | disclosed |
| US-7273876-B2 | Substituted bicylic thiophene derivatives, compositions containing such compounds and methods of use | MERCK & CO., INC. (US) | 2007-09-25 | — | — | US | disclosed |
| US-20050239865-A1 | Substituted bicyclic thiophene derivatives, compositions containing such compounds and methods of use | MERCK SHARP & DOHME CORP. | 2005-10-27 | — | — | US | disclosed |
| WO-1993013104-A1 | C.N.S. ACTIVE TRICYCLIC THIENOPYRIDINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1993-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239865-A1 | Substituted bicyclic thiophene derivatives, compositions containing such compounds and methods of use | GLP1R, GCGR, GPR119 | BPTF 3764/4885MAPT 4485/4885ALDH1A1 4206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.