Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 3/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 6/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 6/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 6/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038259 | 0.88 | GRIA1 (0.38) | PDE9APDE5AGRIA1GRIA2GRIA3 | |
| SCHEMBL29235228 | 0.77 | GRIA1 (0.46) | PDE9APDE5AGRIA1GRIA2GRIA3 | |
| SCHEMBL2468642 | 0.76 | DAO (0.46) | PDE9APDE5AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL31353069 | 0.73 | TP53 (0.60) | PDE9APDE5ACHEK1GABRA5CHEK2 | |
| SCHEMBL4039587 | 0.73 | TYRO3 (0.41) | CHEK1GABRA5CHEK2CDK1GSK3B | |
| SCHEMBL7986801 | 0.72 | GRIN2D (0.50) | PDE9AGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL4038168 | 0.72 | CHEK1 (0.41) | PDE9APDE5AGRIA1GRIA2GRIA3 | |
| SCHEMBL31026861 | 0.72 | CHEK1 (0.41) | PDE9APDE5AGRIA1GRIA2GRIA3 | |
| SCHEMBL30095396 | 0.71 | PARP1 (0.59) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL4763948 | 0.71 | PARP1 (0.59) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | disclosed |
| EP-1463728-B1 | FUSED CYCLIC MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2004078714-A2 | PROCESSES FOR PREPARING IMIDAZOQUINOXALINONES, HETEROCYCLIC-SUBSTITUTED IMIDAZOPYRAZINONES, IMIDAZOUINOXALINES AND HETEROCYCLIC-SUBSTITUTED IMIDAZOPYRAZINES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-09-16 | — | — | WO | disclosed |
| US-20040180898-A1 | Processes for preparing imidazoquinoxalinones, heterocyclic-substituted imidazopyrazinones, imidazoquinoxalines and heterocyclic-substituted imidazopyrazines | BRISTOL-MYERS SQUIBB COMPANY | 2004-09-16 | — | — | US | disclosed |
| US-5990109-A | NOVEL COMPOUNDS, METHODS OF THEIR SYNTHESIS, AND THEIR USE IN TREATING VARIOUS TYROSINE KINASE-ASSOCIATED IMMUNOLOGICAL DISORDERS, SUCH AS RHEUMATOID ARTHRITIS, MULTIPLE SCLEROSIS, GRAFT VS. HOST DISEASE, LUPUS, PSORIASIS AND ASTHMA | BRISTOL-MYERS SQUIBB CO. (US) | 1999-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180898-A1 | Processes for preparing imidazoquinoxalinones, heterocyclic-substituted imidazopyrazinones, imidazoquinoxalines and heterocyclic-substituted imidazopyrazines | NISCH, PDXK, IPO4 | PDE9A 2871/4885PDE5A 2801/4885GRIA1 3530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.