Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RGS4 | P49798 | 5/20 | 0.37 |
| ▸ | RGS8 | P57771 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3867473 | 0.89 | KIF11 (0.56) | KIF11KIF23TP53CYP1A2CYP2C19 | |
| SCHEMBL4037033 | 0.87 | KIF11 (0.49) | KIF11KIF23TP53CYP1A2CYP3A4 | |
| SCHEMBL4037664 | 0.81 | TP53 (0.41) | KIF11KIF23TP53CYP1A2CYP3A4 | |
| SCHEMBL4043250 | 0.79 | KIF11 (0.42) | KIF11TP53CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4219107 | 0.77 | MAPK1 (0.46) | KIF11KIF23TP53CYP1A2CYP3A4 | |
| SCHEMBL3868894 | 0.76 | KIF11 (0.56) | KIF11KIF23TP53CYP1A2CYP2C19 | |
| SCHEMBL5316065 | 0.76 | KIF11 (0.56) | KIF11KIF23TP53CYP1A2CYP2C19 | |
| SCHEMBL3865058 | 0.76 | KIF11 (0.59) | KIF11KIF23TP53CYP1A2CYP2C19 | |
| SCHEMBL4057334 | 0.76 | KIF11 (0.46) | KIF11KIF23TSHRKDM4EGAA | |
| SCHEMBL4066692 | 0.76 | KIF11 (0.48) | KIF11KIF23TSHRKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601673-B1 | FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2009-06-10 | — | — | EP | disclosed |