Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.56 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3865058 | 0.87 | KIF11 (0.59) | KIF11KIF23KDM4ENPSR1GAA | |
| SCHEMBL3867473 | 0.87 | KIF11 (0.56) | KIF11KIF23KDM4ENPSR1GAA | |
| SCHEMBL5742313 | 0.82 | KIF11 (0.58) | KIF11KIF23KDM4ENPSR1GAA | |
| SCHEMBL3868894 | 0.82 | KIF11 (0.56) | KIF11KIF23KDM4ENPSR1GAA | |
| SCHEMBL13871288 | 0.82 | KIF11 (0.53) | KIF11KIF23KDM4ENPSR1GAA | |
| SCHEMBL3864873 | 0.80 | KIF11 (0.49) | KIF11KIF23KDM4ENPSR1GAA | |
| SCHEMBL3892326 | 0.78 | KIF11 (0.49) | KIF11KIF23KDM4ENPSR1GAA | |
| SCHEMBL5316070 | 0.78 | KIF11 (0.47) | KIF11KIF23KDM4ENPSR1GAA | |
| SCHEMBL4039113 | 0.76 | KIF11 (0.47) | KIF11KIF23KDM4ENPSR1GAA | |
| SCHEMBL4037033 | 0.76 | KIF11 (0.49) | KIF11KIF23KDM4ENPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781673-A1 | SELECTED FUSED HETEROCYCLICS AND USES THEREOF | AstraZeneca AB (SE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018627-A1 | SELECTED FUSED HETEROCYCLICS AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |