Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544403 | 0.91 | SLC6A9 (0.40) | SLC6A9S1PR1KDM4ESYKCTSS | |
| SCHEMBL912838 | 0.86 | KDM4E (0.45) | SLC6A9KDM4EALDH1A1SMN1; SMN2HRH1 | |
| SCHEMBL4043788 | 0.85 | MRGPRX4 (0.43) | S1PR1SYKCTSA | |
| Hydrochloric Acid SCHEMBL543829 | 0.83 | NTSR1 (0.39) | SLC6A9S1PR1KDM4ESYKCTSA | |
| Hydrochloric Acid SCHEMBL16493636 | 0.81 | ATM (0.34) | SLC6A9S1PR1KDM4ESYKCTSS | |
| SCHEMBL27869502 | 0.81 | S1PR1 (0.36) | S1PR1KDM4ESYKCTSSCTSK | |
| SCHEMBL2488871 | 0.79 | SLC6A9 (0.46) | SLC6A9KDM4EALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL914386 | 0.78 | SLC6A9 (0.45) | SLC6A9KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL544217 | 0.78 | KDM4E (0.41) | SLC6A9KDM4ECTSAALDH1A1SMN1; SMN2 | |
| SCHEMBL544311 | 0.78 | MRGPRX4 (0.42) | S1PR1SYKCTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2439193-B1 | Derivatives of 5,6-bisaryl-2-pyridine-carboxamide, preparation and use thereof in therapeutics as antagonists of urotensin II receptors | SANOFI SA (FR) | 2014-04-23 | — | — | EP | disclosed |
| EP-2059508-B1 | 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS | SANOFI SA (FR) | 2012-04-11 | — | — | EP | disclosed |
| EP-2059508-A1 | 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS | Sanofi-Aventis (FR) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008020124-A1 | 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS AS UROTENSIN II RECEPTOR ANTAGONISTS | SANOFI-AVENTIS (FR) | 2008-02-21 | — | — | WO | disclosed |