Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27631818 | 0.82 | DAO (0.50) | ATAD2DAOHRH4MAPTCNR2 | |
| SCHEMBL4036808 | 0.81 | DAO (0.51) | ATAD2DAOHRH4MAPTCNR2 | |
| SCHEMBL4039658 | 0.80 | DAO (0.50) | ATAD2DAOHRH4MAPTCNR2 | |
| SCHEMBL29900500 | 0.79 | KDM4E (0.55) | ATAD2DAOHSD17B10HRH4MAPT | |
| SCHEMBL2053643 | 0.79 | KDM4E (0.55) | ATAD2DAOHSD17B10HRH4MAPT | |
| SCHEMBL30568660 | 0.77 | HSD17B10 (0.54) | ATAD2DAOHSD17B10HRH4MAPT | |
| SCHEMBL4067752 | 0.77 | HSD17B10 (0.39) | HSD17B10MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL5260106 | 0.77 | KDM4E (0.48) | DAOHSD17B10MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL6984470 | 0.75 | KDM4E (0.47) | DAOHSD17B10MAPTKDM4EALDH1A1 | |
| SCHEMBL4708000 | 0.74 | DAO (0.48) | DAOMAPTKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |