Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | TSPO | P30536 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12680198 | 0.85 | ALDH1A1 (0.71) | KMT2AALDH1A1POLBMEN1NPC1 | |
| SCHEMBL15625022 | 0.81 | KMT2A (0.62) | KMT2AALDH1A1POLBMEN1NPC1 | |
| SCHEMBL209154 | 0.79 | DRD4 (0.61) | KMT2AALDH1A1NPC1RAB9ASIGMAR1 | |
| SCHEMBL8393982 | 0.79 | EGFR (0.48) | KMT2AALDH1A1POLBMEN1SIGMAR1 | |
| SCHEMBL9989670 | 0.75 | KDM4E (0.61) | KMT2AALDH1A1POLBMEN1NPC1 | |
| SCHEMBL665674 | 0.75 | SIGMAR1 (0.61) | KMT2AALDH1A1POLBMEN1SIGMAR1 | |
| SCHEMBL4558670 | 0.74 | ALDH1A1 (0.50) | KMT2AALDH1A1POLBMEN1SIGMAR1 | |
| SCHEMBL4559554 | 0.74 | DRD4 (0.43) | KMT2AALDH1A1SIGMAR1 | |
| SCHEMBL7676221 | 0.74 | SIGMAR1 (0.56) | KMT2AALDH1A1SIGMAR1GRIN1GRIN2B | |
| SCHEMBL17779041 | 0.73 | KMT2A (0.53) | KMT2AALDH1A1POLBMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009022171-A1 | PYRIDINYIIOXY PYRIDINES AS ALK5 INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | WO | disclosed |