Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | PDE8B | O95263 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039782 | 0.83 | HTR6 (0.39) | MCHR1HTR6DRD2DRD4DRD3 | |
| SCHEMBL6696801 | 0.72 | ROCK2 (0.48) | ROCK2ACHEBCHEHRH3CCR2 | |
| Ammonia Solution, Strong SCHEMBL28610050 | 0.67 | ROCK2 (0.47) | HTR6ROCK2MEN1KMT2AUSP30 | |
| SCHEMBL4896796 | 0.66 | MEN1 (0.54) | HTR6DRD2DRD4DRD3MEN1 | |
| SCHEMBL4896785 | 0.66 | MEN1 (0.54) | HTR6DRD2DRD4DRD3MEN1 | |
| SCHEMBL73760 | 0.65 | HRH3 (0.53) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL14724848 | 0.64 | OPRM1 (0.53) | HTR6DRD2DRD4DRD3MEN1 | |
| SCHEMBL1546751 | 0.63 | HTR6 (0.50) | HTR6DRD2DRD4MEN1KMT2A | |
| SCHEMBL7969987 | 0.62 | LCK (0.66) | ROCK2KMT2AACHEBCHECCR2 | |
| SCHEMBL1546893 | 0.62 | USP30 (0.48) | HTR6DRD2DRD4DRD3USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | claimed |