Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.46 |
| ▸ | BRD4 | O60885 | 4/20 | 0.44 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 3/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP7 | P09237 | 2/20 | 0.36 |
| ▸ | MMP10 | P09238 | 2/20 | 0.36 |
| ▸ | MMP12 | P39900 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039090 | 0.93 | HTR6 (0.46) | KIF11BRD4KIF23GPR119HTR6 | |
| SCHEMBL5899029 | 0.80 | KIF11 (0.47) | KIF11BRD4KIF23TP53 | |
| SCHEMBL3866928 | 0.79 | KIF11 (0.52) | KIF11KIF23 | |
| SCHEMBL3867071 | 0.75 | KIF11 (0.59) | KIF11KIF23 | |
| SCHEMBL4046310 | 0.75 | KIF11 (0.53) | KIF11KIF23 | |
| SCHEMBL4039298 | 0.73 | KIF11 (0.54) | KIF11KIF23 | |
| SCHEMBL4059923 | 0.72 | KIF11 (0.50) | KIF11KIF23TP53 | |
| SCHEMBL3863849 | 0.72 | KIF11 (0.49) | KIF11BRD4KIF23 | |
| SCHEMBL5742313 | 0.71 | KIF11 (0.58) | KIF11KIF23TP53 | |
| SCHEMBL3868894 | 0.71 | KIF11 (0.56) | KIF11KIF23TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601673-B1 | FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2009-06-10 | — | — | EP | disclosed |