SCHEMBL4040191

SCHEMBL4040191

CC(C)(OC[CH]c1nnnn1Cc1ccccc1)C(N)=O

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 2/20 0.45
LMNA P02545 4/20 0.42
POLB P06746 1/20 0.42
SMN1; SMN2 Q16637 3/20 0.40
CYP1A2 P05177 1/20 0.40
SLC16A3 O15427 4/20 0.40
ALDH1A1 P00352 5/20 0.40
TSHR P16473 3/20 0.40
HPGD P15428 2/20 0.40
RAB9A P51151 1/20 0.40
HTT P42858 1/20 0.39
SLC16A1 P53985 2/20 0.38
MCTS1 Q9ULC4 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MAPK1 P28482 1/20 0.38
ALOX15 P16050 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22114391 0.70 LMNA (0.53) LMNAALDH1A1TSHRHPGDRAB9A
SCHEMBL1650741 0.67 SLC16A3 (0.83) POLBCYP1A2SLC16A3ALDH1A1SLC16A1
SCHEMBL6577327 0.64 HPGD (0.54) LMNAALDH1A1TSHRHPGDRAB9A
SCHEMBL4414765 0.64 LMNA (0.57) LMNAPOLBALDH1A1TSHRRAB9A
SCHEMBL2163180 0.63 LMNA (0.59) LMNAALDH1A1TSHRHPGDRAB9A
SCHEMBL11069413 0.63 ALDH1A1 (0.52) LMNAALDH1A1TSHRHPGDRAB9A
SCHEMBL11271744 0.63 HPGD (0.53) LMNAALDH1A1TSHRHPGDRAB9A
SCHEMBL4407828 0.63 ALDH1A1 (0.58) LMNAALDH1A1TSHRMAPK1
SCHEMBL5954845 0.63 CYP19A1 (0.60) LMNAPOLBSMN1; SMN2ALDH1A1TSHR
SCHEMBL1414083 0.63 GHSR (0.53) GHSRLMNAPOLBSMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1463728-B1 FUSED CYCLIC MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION BRISTOL MYERS SQUIBB CO (US) 2009-01-14 EP claimed
EP-1966198-A1 2-AMINO-3,4-DIHYDRO-PYRIDOÝ3,4-D¨PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) JANSSEN PHARMACEUTICA N.V. (BE) 2008-09-10 EP disclosed
WO-2007050612-A1 2-AMINO-3,4-DIHYDRO-PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) JANSSEN PHARMACEUTICA N.V. (BE) 2007-05-03 WO disclosed