Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 19/20 | 0.36 |
| ▸ | CTSK | P43235 | 19/20 | 0.36 |
| ▸ | CTSS | P25774 | 18/20 | 0.36 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | CTSV | O60911 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045875 | 0.93 | CTSK (0.41) | CTSLCTSKCTSSCTSBCTSV | |
| SCHEMBL4048926 | 0.91 | CTSL (0.39) | CTSLCTSKCTSSCTSBCTSV | |
| SCHEMBL4043984 | 0.91 | CTSK (0.39) | CTSLCTSKCTSSCTSBCTSV | |
| SCHEMBL4045509 | 0.90 | PREP (0.33) | CTSKPREPFAP | |
| SCHEMBL4044612 | 0.90 | PREP (0.33) | CTSKPREPFAP | |
| SCHEMBL4040568 | 0.89 | CTSK (0.36) | CTSLCTSKCTSSCTSBCTSV | |
| SCHEMBL4047847 | 0.89 | CTSK (0.38) | CTSLCTSKCTSSCTSBCTSV | |
| SCHEMBL4043056 | 0.87 | HSD17B10 (0.36) | PREPFAP | |
| SCHEMBL4041899 | 0.86 | CTSK (0.39) | CTSLCTSKCTSSPREPFAP | |
| SCHEMBL4051191 | 0.85 | CTSK (0.37) | CTSLCTSKCTSSCTSBCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370561-B1 | TETRAHYDRO-PYRAZINO[1,2-A]INDOLES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS | HOFFMANN LA ROCHE (CH) | 2009-02-11 | — | — | EP | claimed |