Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CLK1 | P49759 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
| ▸ | FAP | Q12884 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041872 | 0.93 | CTSK (0.38) | HSD17B10HCRTR2KCNQ1LMNACLK1 | |
| SCHEMBL4051011 | 0.91 | HCRTR2 (0.34) | HSD17B10HCRTR2KCNQ1LMNACLK1 | |
| SCHEMBL4051650 | 0.91 | HSD17B10 (0.36) | HSD17B10HCRTR2KCNQ1LMNACLK1 | |
| SCHEMBL4044199 | 0.90 | SMYD3 (0.34) | TSHRSMYD3 | |
| SCHEMBL4042699 | 0.90 | CTSK (0.32) | PREPFAP | |
| SCHEMBL6238658 | 0.90 | HSD17B10 (0.37) | HSD17B10HCRTR2KCNQ1LMNACLK1 | |
| SCHEMBL4039560 | 0.90 | HCRTR2 (0.33) | HSD17B10HCRTR2KCNQ1LMNACLK1 | |
| SCHEMBL4047006 | 0.89 | HSD17B10 (0.38) | HSD17B10HCRTR2KCNQ1LMNASMN1; SMN2 | |
| SCHEMBL4040945 | 0.89 | CTSK (0.31) | — | |
| SCHEMBL4041176 | 0.87 | CTSL (0.36) | PREPFAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010518-A1 | AZABICYCLO [3. 1. O] HEXANE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007113258-A1 | AZABICYCLO [3. 1. O] HEXANE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2007-10-11 | — | — | WO | disclosed |