Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 2/20 | 0.38 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041320 | 0.86 | PLA2G10 (0.38) | PLA2G10PLA2G5CXCR3ALDH1A1LMNA | |
| SCHEMBL4034900 | 0.85 | CXCR3 (0.40) | CXCR3ALDH1A1LMNAHDAC8GAA | |
| SCHEMBL10326470 | 0.81 | PLA2G10 (0.45) | PLA2G10PLA2G5CXCR3ALDH1A1HDAC8 | |
| SCHEMBL10326656 | 0.81 | PLA2G10 (0.45) | PLA2G10PLA2G5CXCR3ALDH1A1HDAC8 | |
| SCHEMBL10327298 | 0.81 | PLA2G10 (0.45) | PLA2G10PLA2G5CXCR3ALDH1A1HDAC8 | |
| SCHEMBL3917588 | 0.81 | PLA2G10 (0.39) | PLA2G10PLA2G5CXCR3ALDH1A1HDAC8 | |
| SCHEMBL4038603 | 0.79 | ATM (0.42) | CXCR3ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL1801279 | 0.79 | ALDH1A1 (0.39) | PLA2G10PLA2G5ALDH1A1LMNAKMT2A | |
| SCHEMBL4034635 | 0.79 | HDAC8 (0.35) | ALDH1A1HDAC8KMT2AGAA | |
| SCHEMBL1803072 | 0.78 | GRM5 (0.48) | ALDH1A1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |