Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | HTR2B | P41595 | 2/20 | 0.54 |
| ▸ | HTR5A | P47898 | 2/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.51 |
| ▸ | AKT2 | P31751 | 3/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042003 | 0.76 | MAPT (0.54) | MAPTMAPK1LMNASMN1; SMN2HTR2C | |
| SCHEMBL31512553 | 0.76 | MAPT (0.54) | MAPTMAPK1LMNASMN1; SMN2HTR2C | |
| SCHEMBL28765140 | 0.75 | AKT2 (0.52) | MAPK1LMNASMN1; SMN2PIK3CAAKT2 | |
| SCHEMBL2938675 | 0.74 | AKT2 (0.70) | AKT2MAPK14 | |
| SCHEMBL16939183 | 0.73 | JAK2 (0.58) | MAPTMAPK1LMNASMN1; SMN2HTR2C | |
| SCHEMBL18486241 | 0.72 | PIK3CA (0.46) | MAPTMAPK1LMNASMN1; SMN2HTT | |
| SCHEMBL29761049 | 0.72 | AKT2 (0.46) | LMNAPIK3CAAKT2PIK3CBPIK3CG | |
| SCHEMBL5249231 | 0.72 | CDK5 (0.50) | MAPTMAPK1LMNASMN1; SMN2HTT | |
| SCHEMBL8707173 | 0.72 | AKT2 (0.47) | MAPTLMNASMN1; SMN2HTTPIK3CA | |
| SCHEMBL7027580 | 0.71 | MAPK14 (0.47) | MAPTAKT2MEN1KMT2AMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002018404-A9 | NUCLEOSIDE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C | HOFFMANN LA ROCHE (CH) | 2003-10-02 | — | — | WO | disclosed |
| EP-1315736-A2 | NUCLEOSIDE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-04 | — | — | EP | disclosed |
| WO-2002018404-A2 | NUCLEOSIDE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-07 | — | — | WO | disclosed |