Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.38 |
| ▸ | RHEB | Q15382 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033692 | 0.92 | RHEB (0.42) | TGFBR1TGFBR2RHEBALDH1A1NPC1 | |
| SCHEMBL4034813 | 0.88 | PKM (0.43) | TGFBR1TGFBR2RHEBALDH1A1HPGD | |
| SCHEMBL4035489 | 0.84 | SLC6A4 (0.43) | TGFBR1TGFBR2RHEBALDH1A1HPGD | |
| SCHEMBL4036827 | 0.84 | KDM4E (0.43) | TGFBR1TGFBR2RHEBALDH1A1HPGD | |
| SCHEMBL4035286 | 0.84 | PTPN11 (0.38) | TGFBR1TGFBR2RHEBHPGDKDM4E | |
| SCHEMBL4035241 | 0.84 | MAP2 (0.41) | TGFBR1TGFBR2RHEBALDH1A1HPGD | |
| SCHEMBL4041261 | 0.80 | RHEB (0.44) | RHEBALDH1A1HPGDNPC1LMNA | |
| SCHEMBL4214923 | 0.80 | ALDH1A1 (0.37) | TGFBR1RHEBALDH1A1LMNAL3MBTL1 | |
| SCHEMBL4036107 | 0.79 | PDE5A (0.36) | TGFBR1TGFBR2ALDH1A1HPGDKDM4E | |
| SCHEMBL4041978 | 0.79 | CNR2 (0.35) | TGFBR1TGFBR2RHEBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |