Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035502 | 0.89 | TUBB4A (0.39) | SLC6A4PTGDR2ALDH1A1PARP1MEN1 | |
| SCHEMBL4032967 | 0.88 | SMN1; SMN2 (0.41) | SLC6A4PTGDR2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4033192 | 0.88 | PKN1 (0.38) | PARP1MEN1KMT2ACHEK2 | |
| SCHEMBL4036827 | 0.88 | KDM4E (0.43) | KDM4EALDH1A1HPGDTGFBR1TGFBR2 | |
| SCHEMBL4042064 | 0.84 | TGFBR1 (0.38) | KDM4EALDH1A1CYP3A4HPGDTGFBR1 | |
| SCHEMBL4033692 | 0.84 | RHEB (0.42) | ALDH1A1TGFBR1TGFBR2L3MBTL1RAB9A | |
| SCHEMBL4039619 | 0.84 | MAPT (0.46) | KDM4EALDH1A1HPGDPARP1L3MBTL1 | |
| SCHEMBL4034008 | 0.83 | LMNA (0.37) | TGFBR1TGFBR2PARP1KMT2ALMNA | |
| SCHEMBL4034813 | 0.83 | PKM (0.43) | KDM4EALDH1A1CYP3A4HPGDTGFBR1 | |
| SCHEMBL2053450 | 0.82 | SLC6A4 (0.45) | SLC6A4PTGDR2KDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |