Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 5/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037470 | 0.91 | GAA (0.44) | GAAKMT2ACCR5CXCR3HTT | |
| SCHEMBL3927067 | 0.89 | GAA (0.37) | GAAKMT2ACCR5CXCR3HTT | |
| SCHEMBL4034816 | 0.88 | GAA (0.34) | GAAKMT2ACCR5CXCR3HTT | |
| SCHEMBL4035046 | 0.86 | GAA (0.35) | GAAKMT2ACCR5CXCR3SIGMAR1 | |
| SCHEMBL3919512 | 0.86 | GAA (0.39) | GAAKMT2ACCR5CXCR3ALDH1A1 | |
| SCHEMBL4033395 | 0.85 | MCHR1 (0.36) | GAAKMT2ASIGMAR1CYP3A4CYP2D6 | |
| SCHEMBL4040751 | 0.83 | HTT (0.38) | HTTPOLB | |
| SCHEMBL4035720 | 0.83 | TP53 (0.35) | KMT2ACCR5HTTALDH1A1POLB | |
| SCHEMBL2940213 | 0.83 | RIPK1 (0.42) | GAAKMT2AHTTCHRM2CYP3A4 | |
| SCHEMBL1801114 | 0.83 | RIPK1 (0.42) | GAAKMT2AHTTCHRM2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730144-B1 | SUBSTITUTED 1,4,8-TRIAZASPIRO¬4.5 DECAN-2-ONE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-06-10 | — | — | EP | claimed |