Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 18/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041226 | 0.83 | LCK (0.53) | LCKFGFR1KDR | |
| SCHEMBL4042263 | 0.82 | LCK (0.47) | LCKFGFR1KDR | |
| SCHEMBL4041458 | 0.81 | LCK (0.53) | LCK | |
| SCHEMBL7979958 | 0.78 | LCK (0.56) | LCK | |
| SCHEMBL4043849 | 0.77 | LCK (0.43) | LCKFGFR1 | |
| SCHEMBL7982713 | 0.76 | LCK (0.51) | LCK | |
| SCHEMBL4038826 | 0.75 | FGFR1 (0.49) | LCKFGFR1KDR | |
| SCHEMBL4038945 | 0.74 | LCK (0.50) | LCK | |
| SCHEMBL7983111 | 0.74 | LCK (0.58) | LCK | |
| SCHEMBL4042434 | 0.71 | LCK (0.41) | LCKFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | claimed |
| EP-1066286-B1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2009-04-29 | — | — | EP | disclosed |