Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PTPRC | P08575 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3192100 | 0.74 | ALDH1A1 (0.48) | MEN1KMT2AIDO1ALDH1A1HSD17B10 | |
| SCHEMBL28893697 | 0.73 | ADORA2A (0.33) | MEN1KMT2AIDO1ALDH1A1HSD17B10 | |
| SCHEMBL9462900 | 0.73 | CYP2A6 (0.39) | MEN1KMT2AIDO1ALDH1A1HSD17B10 | |
| SCHEMBL9064845 | 0.73 | KDM4E (0.31) | MEN1KMT2AIDO1ALDH1A1HSD17B10 | |
| SCHEMBL18243665 | 0.73 | KDM4E (0.31) | MEN1KMT2AIDO1ALDH1A1HSD17B10 | |
| SCHEMBL246576 | 0.73 | ALDH1A1 (0.39) | MEN1KMT2AIDO1ALDH1A1HSD17B10 | |
| SCHEMBL216981 | 0.73 | ACHE (0.39) | ALDH1A1LMNAACHE | |
| SCHEMBL28964468 | 0.73 | KDM4E (0.31) | MEN1KMT2AIDO1ALDH1A1HSD17B10 | |
| SCHEMBL216861 | 0.73 | ALDH1A1 (0.44) | ALDH1A1HSD17B10HPGD | |
| SCHEMBL28343841 | 0.73 | KDM4E (0.31) | MEN1KMT2AIDO1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1438288-B1 | SUBSTITUTED THIOACETAMIDES | CEPHALON INC (US) | 2009-04-29 | — | — | EP | disclosed |
| US-20080027228-A1 | Substituted thioacetamides | CEPHALON, INC. (US) | 2008-01-31 | — | — | US | disclosed |
| US-7268132-B2 | Thio substituted with a hetero multiring group; sleepiness, promotion of wakefulness, Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, attention deficit hyperactivity disorder | CEPHALON, INC. (US) | 2007-09-11 | — | — | US | disclosed |
| US-20050192313-A1 | Substituted thioacetamides | CEPHALON, INC. (US) | 2005-09-01 | — | — | US | disclosed |
| US-6919367-B2 | Substituted thioacetamides | CEPHALON, INC. (US) | 2005-07-19 | — | — | US | disclosed |
| EP-1438288-A1 | SUBSTITUTED THIOACETAMIDES | CEPHALON, INC. (US) | 2004-07-21 | — | — | EP | disclosed |
| US-20040116445-A1 | Substituted thioacetamides | CEPHALON INC. | 2004-06-17 | — | — | US | disclosed |
| US-6670358-B2 | Substituted thioacetamides | CEPHALON, INC. | 2003-12-30 | — | — | US | disclosed |
| WO-2003037853-A1 | SUBSTITUTED THIOACETAMIDES | CEPHALON, INC. (US) | 2003-05-08 | — | — | WO | disclosed |
| US-20020183334-A1 | Substituted thioacetamides | CEPHALON, INC. | 2002-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027228-A1 | Substituted thioacetamides | TST, TTR, TBCA | MEN1 3755/4885KMT2A 1970/4885IDO1 1868/4885 |
| US-20020183334-A1 | Substituted thioacetamides | TST, TTR, TBCA | MEN1 3755/4885KMT2A 1970/4885IDO1 1868/4885 |
| US-20050192313-A1 | Substituted thioacetamides | TST, TTR, TBCA | MEN1 3755/4885KMT2A 1970/4885IDO1 1868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.