Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CLK1 | P49759 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051650 | 0.92 | HSD17B10 (0.36) | CTSKHCRTR2HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL4041872 | 0.90 | CTSK (0.38) | CTSKHCRTR2HSD17B10MMP1MMP3 | |
| SCHEMBL4041363 | 0.90 | CTSK (0.42) | CTSKUTS2RMMP1MMP3MMP9 | |
| SCHEMBL4042904 | 0.90 | CTSK (0.39) | CTSKMMP1MMP3MMP9TAS1R3 | |
| SCHEMBL4040677 | 0.89 | CTSK (0.41) | CTSKHCRTR2HSD17B10MMP1MMP3 | |
| SCHEMBL4049257 | 0.88 | CTSK (0.41) | CTSKUTS2RTAS1R3TAS1R1TRPV4 | |
| SCHEMBL4037989 | 0.88 | CTSK (0.42) | CTSKHCRTR2HSD17B10MMP1MMP3 | |
| SCHEMBL4039608 | 0.87 | CTSK (0.45) | CTSK | |
| SCHEMBL4049190 | 0.87 | CTSK (0.40) | CTSKHCRTR2HSD17B10KMT2AKCNQ1 | |
| SCHEMBL4043843 | 0.86 | CTSK (0.41) | CTSKHCRTR2HSD17B10MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |