Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CLK1 | P49759 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | CTSB | P07858 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043056 | 0.93 | HSD17B10 (0.36) | HCRTR2HSD17B10KCNQ1SMN1; SMN2LMNA | |
| SCHEMBL4051011 | 0.92 | HCRTR2 (0.34) | HCRTR2HSD17B10KCNQ1SMN1; SMN2LMNA | |
| SCHEMBL4044312 | 0.90 | CTSK (0.40) | CTSKHCRTR2HSD17B10KCNQ1SMN1; SMN2 | |
| SCHEMBL4039560 | 0.90 | HCRTR2 (0.33) | CTSKHCRTR2HSD17B10KCNQ1SMN1; SMN2 | |
| SCHEMBL4045303 | 0.90 | CTSK (0.37) | CTSKSMYD3CTSLCTSBCTSS | |
| SCHEMBL4047331 | 0.90 | CTSK (0.40) | CTSKMMP1MMP3MMP9CTSL | |
| SCHEMBL4049190 | 0.89 | CTSK (0.40) | CTSKHCRTR2HSD17B10KCNQ1KMT2A | |
| SCHEMBL4049345 | 0.88 | CTSK (0.38) | CTSKCTSLCTSBCTSS | |
| SCHEMBL4045875 | 0.87 | CTSK (0.41) | CTSKCTSLCTSBCTSS | |
| SCHEMBL4042884 | 0.85 | CTSK (0.41) | CTSKMMP1MMP3MMP9CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |