Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.41 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 3/20 | 0.35 |
| ▸ | CTSB | P07858 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045961 | 0.93 | CTSK (0.39) | CTSKELOVL6MMP1MMP3MMP9 | |
| SCHEMBL4044730 | 0.92 | LMNA (0.39) | CTSKELOVL6MMP1MMP3MMP9 | |
| SCHEMBL4051777 | 0.91 | CTSK (0.44) | CTSKELOVL6MMP1MMP3MMP9 | |
| SCHEMBL4050147 | 0.90 | CTSK (0.40) | CTSKMMP1MMP3MMP9CTSL | |
| SCHEMBL4043183 | 0.90 | CTSK (0.43) | CTSKMMP1MMP3MMP9ALDH1A1 | |
| SCHEMBL4046660 | 0.89 | HTT (0.40) | CTSKELOVL6ALDH1A1LMNAKCNQ1 | |
| SCHEMBL4044312 | 0.89 | CTSK (0.40) | CTSKMMP1MMP3MMP9LMNA | |
| SCHEMBL4039165 | 0.89 | CTSK (0.40) | CTSKELOVL6MMP1MMP3MMP9 | |
| SCHEMBL4039525 | 0.88 | CTSK (0.42) | CTSKALDH1A1LMNACCR4CTSL | |
| SCHEMBL4043843 | 0.88 | CTSK (0.41) | CTSKMMP1MMP3MMP9HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |