Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Testosterone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR known ✓ | P10275 | 5/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.85 |
| ▸ | LMNA | P02545 | 7/20 | 0.85 |
| ▸ | TSHR | P16473 | 5/20 | 0.85 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.85 |
| ▸ | MAPT | P10636 | 5/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.85 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.85 |
| ▸ | PGR | P06401 | 4/20 | 0.85 |
| ▸ | SHBG | P04278 | 4/20 | 0.85 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.85 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.85 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.85 |
| ▸ | SNCA | P37840 | 2/20 | 0.85 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.85 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.85 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.85 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Testosterone SCHEMBL2907975 | 1.00 | CYP3A4 (0.85) | CYP3A4LMNATSHRARCYP19A1 | |
| Testosterone SCHEMBL9011200 | 0.94 | CYP3A4 (0.85) | CYP3A4LMNATSHRARCYP19A1 | |
| Testosterone SCHEMBL8814300 | 0.93 | LMNA (0.93) | CYP3A4LMNATSHRARCYP19A1 | |
| Testosterone SCHEMBL11226131 | 0.93 | LMNA (0.80) | CYP3A4LMNATSHRARCYP19A1 | |
| Testosterone SCHEMBL8075829 | 0.93 | LMNA (0.83) | CYP3A4LMNATSHRARCYP19A1 | |
| Testosterone SCHEMBL17221034 | 0.92 | CYP3A4 (0.91) | CYP3A4LMNATSHRARCYP19A1 | |
| Testosterone SCHEMBL547899 | 0.92 | LMNA (0.91) | CYP3A4LMNATSHRARCYP19A1 | |
| Epitestosterone SCHEMBL13752937 | 0.92 | AR (1.00) | CYP3A4LMNATSHRARCYP19A1 | |
| Epitestosterone SCHEMBL11588466 | 0.92 | AR (1.00) | CYP3A4LMNATSHRARCYP19A1 | |
| Epitestosterone SCHEMBL21957465 | 0.92 | AR (1.00) | CYP3A4LMNATSHRARCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 18043 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122063219-A | Method for simultaneously measuring 31 stimulant substances in complex matrix cosmetics | 国家体育总局反兴奋剂中心(中国反兴奋剂中心) | 2026-05-19 | — | — | CN | claimed |
| EP-3978473-B1 | COMPOUND CONTAINING AN INDOLEACETIC ACID CORE STRUCTURE AND USE THEREOF | BEIJING AN JIAN XI BIO MEDICAL TECH CO LTD (CN) | 2026-05-06 | — | — | EP | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20260076978-A1 | COMPOSITIONS FOR NON-SURGICAL PREVENTION OF BOAR TAINT AND AGGRESSIVE BEHAVIOR | INSIGNA INC (US) | 2026-03-19 | — | — | US | claimed |
| US-20250325560-A1 | METHODS FOR IMPROVING MUSCLE MASS, STRENGTH, OR FUNCTION WITH A COMBINATION OF TESTOSTERONE AND GROWTH HORMONE | UNIVERSITY OF ROCHESTER (US) | 2025-10-23 | — | — | US | claimed |
| US-12383563-B2 | Methods of reducing mammographic breast density and/or breast cancer risk | Havah Therapeutics Pty Ltd. (AU) | 2025-08-12 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-12364682-B2 | Use of tegaserod in preparation of anti-tumor drug | QINGDAO HAIJI BIOMEDICINE CO., LTD. (CN) | 2025-07-22 | — | — | US | claimed |
| US-12310928-B2 | Enthesis healing | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2025-05-27 | — | — | US | claimed |
| US-20250144021-A1 | GEL FORMULATIONS FOR LOCAL DRUG RELEASE | TECHNICAL UNIVERSITY OF DENMARK (DK) | 2025-05-08 | — | — | US | claimed |
| EP-0391369-A2 | Medicinal emulsions | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1990-10-10 | — | — | EP | claimed |
| EP-0265350-B1 | NOVEL PLATINUM-STEROID COMPLEXES | Kidani, Yoshinori (JP) | 1989-11-15 | — | — | EP | claimed |
| US-4879379-A | ANTITUMOR, DIAMINE OR AMMONIA LIGANDS | Kidani, Yoshinori (JP) | 1989-11-07 | — | — | US | claimed |
| EP-0265350-A1 | Novel platinum-steroid complexes | Kidani, Yoshinori (JP) | 1988-04-27 | — | — | EP | claimed |
| US-4563351-A | SUSTAINED RELEASE | FORSYTH DENTAL INFIRMARY FOR CHILDREN (US) | 1986-01-07 | — | — | US | claimed |
| US-4346709-A | Drug delivery devices comprising erodible polymer and erosion rate modifier | ALZA CORPORATION (US) | 1982-08-31 | — | — | US | claimed |
| US-4252799-A | ANDROGENS, MEATS, PREVENT MATURATION | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE A NOT-FORPROFIT CORP. | 1981-02-24 | — | — | US | claimed |
| US-4053580-A | POLYSILOXANE, POLYOXYETHYLENE GLYCOL | G. D. SEARLE & CO. (US) | 1977-10-11 | — | — | US | claimed |
| US-3960757-A | HYDROPHOBIC | TOYO JOZO CO., LTD. (JA) | 1976-06-01 | — | — | US | claimed |
| US-3946106-A | POLYSILOXANES | G. D. SEARLE & CO. (US) | 1976-03-23 | — | — | US | claimed |