Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Testosterone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR known ✓ | P10275 | 5/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.85 |
| ▸ | LMNA | P02545 | 7/20 | 0.85 |
| ▸ | TSHR | P16473 | 5/20 | 0.85 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.85 |
| ▸ | MAPT | P10636 | 5/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.85 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.85 |
| ▸ | PGR | P06401 | 4/20 | 0.85 |
| ▸ | SHBG | P04278 | 4/20 | 0.85 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.85 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.85 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.85 |
| ▸ | SNCA | P37840 | 2/20 | 0.85 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.85 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.85 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.85 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Testosterone SCHEMBL4045 | 1.00 | CYP3A4 (0.85) | CYP3A4LMNATSHRARCYP19A1 | |
| Testosterone SCHEMBL9011200 | 0.94 | CYP3A4 (0.85) | CYP3A4LMNATSHRARCYP19A1 | |
| Testosterone SCHEMBL8814300 | 0.93 | LMNA (0.93) | CYP3A4LMNATSHRARCYP19A1 | |
| Testosterone SCHEMBL11226131 | 0.93 | LMNA (0.80) | CYP3A4LMNATSHRARCYP19A1 | |
| Testosterone SCHEMBL8075829 | 0.93 | LMNA (0.83) | CYP3A4LMNATSHRARCYP19A1 | |
| Testosterone SCHEMBL17221034 | 0.92 | CYP3A4 (0.91) | CYP3A4LMNATSHRARCYP19A1 | |
| Testosterone SCHEMBL547899 | 0.92 | LMNA (0.91) | CYP3A4LMNATSHRARCYP19A1 | |
| Epitestosterone SCHEMBL13752937 | 0.92 | AR (1.00) | CYP3A4LMNATSHRARCYP19A1 | |
| Epitestosterone SCHEMBL11588466 | 0.92 | AR (1.00) | CYP3A4LMNATSHRARCYP19A1 | |
| Epitestosterone SCHEMBL21957465 | 0.92 | AR (1.00) | CYP3A4LMNATSHRARCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9393218-B2 | Use of film-forming hair care polymers from the group of polyurethanes and pharmaceutical preparations and patches that contain these polymers | EPINAMICS GMBH (DE) | 2016-07-19 | — | — | US | claimed |
| EP-1962815-B1 | USE OF FILM-FORMING HAIR-CARE POLYMERS FROM THE GROUP OF POLYURETHANES AND PHARMACEUTICAL PREPARATIONS AND PLASTERS CONTAINING SAID POLYMERS | EPINAMICS GMBH (DE) | 2010-08-11 | — | — | EP | claimed |
| US-20070248658-A1 | Use of film-forming hair care polymers from the group of polyurethanes and pharmaceutical preparations and patches that contain these polymers | EPINAMICS GMBH (DE) | 2007-10-25 | — | — | US | claimed |
| WO-2023223235-A1 | LIPOSOMAL PREPARATION WITH ENCAPSULATED HORMONES, METHOD OF PRODUCTION AND USE THEREOF | PURNA PHARMACEUTICALS NV (BE) | 2023-11-23 | — | — | WO | disclosed |
| US-9393218-B2 | Use of film-forming hair care polymers from the group of polyurethanes and pharmaceutical preparations and patches that contain these polymers | EPINAMICS GMBH (DE) | 2016-07-19 | — | — | US | disclosed |
| US-20070248658-A1 | Use of film-forming hair care polymers from the group of polyurethanes and pharmaceutical preparations and patches that contain these polymers | EPINAMICS GMBH (DE) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070248658-A1 | Use of film-forming hair care polymers from the group of polyurethanes and pharmaceutical preparations and patches that contain these polymers | CUTA, PUF60, TET3 | AR 1194/4885CYP3A4 2372/4885LMNA 1499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.