Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.39 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048276 | 0.86 | BRAF (0.42) | BRAFMAPK14KDRMAPK13RAF1 | |
| SCHEMBL4045295 | 0.82 | BRAF (0.46) | BRAFCYP46A1MAPK14KDRKDM4E | |
| SCHEMBL4047106 | 0.68 | BRAF (0.51) | BRAFMAPK14KDRMAPK13RAF1 | |
| SCHEMBL3657571 | 0.65 | BRAF (0.49) | BRAFKDM4EALDH1A1KMT2A | |
| SCHEMBL3656568 | 0.65 | BRAF (0.51) | BRAFMAPK14KDM4ELMNAHSD17B10 | |
| SCHEMBL8576094 | 0.65 | MAPK14 (0.51) | BRAFMAPK14MAPK13RAF1MAPK12 | |
| SCHEMBL16359117 | 0.64 | DGAT2 (0.38) | BRAFKDM4EHSD17B10ALDH1A1BTK | |
| SCHEMBL4048461 | 0.64 | BRAF (0.49) | BRAFMAPK14KDRMAPK13RAF1 | |
| SCHEMBL30111021 | 0.62 | ESR1 (0.46) | HSD17B10ALDH1A1 | |
| SCHEMBL15855842 | 0.62 | NPC1 (0.51) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108827-A1 | FUSED TRICYCLIC PYRAZOLO[1, 5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | disclosed |