Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.41 |
| ▸ | NCK1 | P16333 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 4/20 | 0.39 |
| ▸ | NOS3 | P29474 | 3/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045372 | 0.81 | PLAU (0.43) | BACE1NCK1NOS2PLAUNCF1 | |
| SCHEMBL24284152 | 0.81 | CYP1A2 (0.43) | KDM4ELMNAPOLBCASP6ALDH1A1 | |
| SCHEMBL25933730 | 0.76 | CYP1A2 (0.31) | ALDH1A1CYP1A2MET | |
| SCHEMBL25449341 | 0.76 | BACE1 (0.38) | BACE1NCK1NOS2NOS3NOS1 | |
| SCHEMBL5802570 | 0.72 | NOS2 (0.48) | BACE1NCK1NOS2NOS3NOS1 | |
| SCHEMBL25748417 | 0.72 | BACE1 (0.54) | BACE1NCK1NOS2NOS3NOS1 | |
| SCHEMBL6644292 | 0.70 | PLAU (0.40) | BACE1NCK1NOS2NOS3NOS1 | |
| SCHEMBL31663159 | 0.70 | PLAU (0.40) | BACE1NCK1NOS2NOS3NOS1 | |
| SCHEMBL3638905 | 0.70 | PLAU (0.40) | BACE1NCK1NOS2NOS3NOS1 | |
| SCHEMBL14656791 | 0.69 | KDM4E (0.38) | BACE1NOS2NOS3NOS1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023025912-A1 | USE OF GCN2 INHIBITORS IN TREATING CANCER | Alesta Therapeutics BV (NL) | 2023-03-02 | — | — | WO | disclosed |